1. Sample formulations:Acetaminophen formulation with F-MELT® Type C and M
A 30-40% load of acetaminophen may bring down the tablet hardness to a region between 30 and 35 N while maintaining a disintegration time of 30 seconds. At higher compression forces, the oral disintegration time tends to increase slightly.
A strategy to overcome this limitation was developed by Fuji scientists to maintain tablet hardness of 50 N and an oral disintegration time of 30 seconds.
Strategy for preparing high quality F-MELT® tablets
By changing the lubricant, formulators could avoid adding additional excipients to achieve a higher tablet hardness and a disintegration time of less than 30 seconds.
3. F-MELT® sample formulation with L-Ascorbic acid. Effect of two different types of lubricants (sodium stearyl fumarate and magnesium stearate) on tablet hardness, oral disintegration time and friability
Tabletting conditions: Φ8 mm, 200 mg/tablet rotary:15rpm.
Ascorbic acid, a highly hygroscopic active was successfully formulated into an oral disintegrating tablet with F-MELT®. In order to avoid the sticking/capping, 0.5% of talc was included in the formulation