Nutraceutical Application

CONTENTS

Sample formulations Type C

1. Vitamin B12 Formulation with F-MELT® Type C

Vitamin B12 is a water soluble vitamin which is required for proper red blood cell formation, neurological function and DNA synthesis. It is widely accepted as a dietary supplement and is consumed in microgram dosages. Oral Disintegrating Vitamin B12 nutraceutical tablets were prepared with F-MELT® type C.

This example shows a 500 μg Vitamin B12 preparation with F-MELT® Type C.

Vitamin B12 formulation with F-MELT® Type C (500 μg/tablet)
Batch Formula
Batch Formula
Blending steps
Blending steps
Tabletting Condition: Rotary tabletting machine (HT-AP18SS) at 15 rpm. Compression force of 4.8 - 5.2 KN
F-MELT® Vitamin B12 Characteristics（10Φ 300 mg flat tablet)

2. CoQ10 Formulation with F-MELT® Type C

CoQ10 is a well established dietary supplement. This example shows successful tablet formulations of 350 mg and 1200 mg oral disintegrating tablets of CoQ10 at 17.5 to 60 mg load.

Smooth Water soluble CoQ10 (5% - 17.5 to 60 mg) OD Tablet Formulation

Batch Formula
Batch Formula

Tabletting Condition: Rotary tabletting machine (HT-AP18SS) at 15 rpm

F-MELT® CoQ10 tablets φ10 mm 350 mg, (CoQ10 - 17.5 mg)F-MELT® CoQ10 tablets φ10 mm 350 mg, (CoQ10 - 17.5 mg)
CoQ10: Molecular weight: 863 Melting point: ca 48℃. Yellowish or orange colored crystal powder
Additional excipients like MCC and CMC and Talc were included to improve tablet properties

Sample formulations F1

1. Vitamin B12 formulation with F-MELT® F1

Vitamin B12 is a water soluble vitamin which is required for proper red blood cell formation, neurological function and DNA synthesis. It is widely accepted as a dietary supplement and is consumed in microgram dosages. Oral disintegrating Vitamin B12 (500 μg) nutraceutical tablets were prepared with F-MELT® F1.

Vitamin B12 tablet: ø 10 mm, 300 mg/tablet (V.B12 500 μg/tablet)
Vitamin B12 tablet Vitamin B12 tablet
Compression Force: 3.9-4.0 kN
Tablet Hardness: 59.8 N
Oral Disintegration Time : 30 sec

2. Improvement of commercially available multivitamin-mineral tablet with F-MELT® F1

Sugars and cellulose in original formulation were replaced with F-MELT® F1.

Iron, Copper, VB12 tablet: ø 8 mm, 240 mg per tablet (4 tablets per day)
Iron, Copper, VB12 tablet
Iron: 6 mg, Copper: 0.9 mg, B6: 1.6 mg, B12: 2.4 μg, Folic acid: 200 μg
Iron, Copper, VB12 tablet propertiesIron, Copper, VB12 tablet properties
Iron, Copper, VB12 tablet propertiesIron, Copper, VB12 tablet properties
Drastic improvement in disintegration time with F-MELT® F1
Drastic improvement in disintegration time with F-MELT® F1

3. Improvement of Zinc commercial tablet with F-MELT® F1

Sugars and cellulose in original formulation were replaced with F-MELT® F1

Zinc, Selenium, Chrome tablet: ø 8 mm, 250 mg per tablet (4 tablets per day)
Zinc, Selenium, Chrome tablet: ø 8 mm, 250 mg per tablet (4 tablets per day)
Zinc: 15mg, Selenium: 50μg, Chrome: 50μg
Zinc, Selenium, Chrome tablet propertiesZinc, Selenium, Chrome tablet properties
Zinc, Selenium, Chrome tablet propertiesZinc, Selenium, Chrome tablet properties
Considerable improvement in disintegration time with F-MELT® F1
Considerable improvement in disintegration time with F-MELT® F1